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- 2022 | Chem. Eur. J. | Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor
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- 2020 | Org. Process Res. Dev. | Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow
- 2020 | React. Chem. Eng. | An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride
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Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor
Photo-transformation: Unlike classical enantiomeric resolution methods, crystallization-induced diastereomer transformations (CIDTs) allow full conversion to the desired enantiomer. Using photochemical racemization for a CIDT has not before been published in the scientific literature. We report the use of an oscillatory flow reactor for efficient irradiation, allowing high yield and >95 % ee to be achieved in a reaction time of just a few hours.
Dr. Jason D. Williams, Dr. Peter Pöchlauer, Dr. Yoshiyuki Okumura, Yukari Inami, Prof. Dr. C. Oliver Kappe, Chemistry A European Journal, 2022, DOI: 10.1002/chem.202200741
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/chem.202200741