- Home
- COSTA™ Technology
- Products
- HANU™ Flow Reactors
- Laboratory R&D
- HANU™ 2X 5
- Accessories
- Inlays
- HANU™ 2X 5 Inlay, cubic 2x2, stainless steel
- HANU™ 2X 5 Inlay, cubic 2x2, Hastelloy
- HANU™ 2X 5 Inlay, cubic 2x2, copper
- HANU™ 2X 5 Inlay, cubic 2x2, PTFE
- HANU™ 2X 5 Inlay, cubic 2x2, silicon carbide
- HANU™ 2X 5 Inlay, cubic 2x2, PEEK
- HANU™ 2X 5 Inlay, cubic 2x2, titanium
- HANU™ 2X 5 Inlay, cubic 1x1, Hastelloy
- HANU™ 2X 5 Inlay, cubic 1x1, Stainless steel
- In/outlet Ports
- Consumables
- Miscellaneous
- Inlays
- Accessories
- HANU™ 2X 5
- Process Development
- Pilot/Production
- Laboratory R&D
- MPDS® for Photochemistry
- Electrochemistry
- Previous Models
- HANU™ Flow Reactors
- Applications
- Application Notes
- Application Note 5: Electrochemical Oxidation of Diphenyl Sulfide enabled by the FAVO™ 5 Flow Reactor
- Application Note 4: Temperature Control in the HANU™ PX 9 Parallel Photoreactor
- Application Note 3: The use of the HANU™ reactor in combination with non-invasive inline Raman spectroscopy as a tool for a real
- Application Note 2: Photoinitiated thiol-ene coupling in flow
- Application Note 1: Synthesis of Cookson’s diketone via intramolecular [2+2] photocycloaddition
- Publications
- Scientific Publications
- 2022 | Chem. Eur. J. | Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor
- 2021 | Green Chem. | Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions
- 2021 | Green Chem. | Continuous Flow Processing of Bismuth-Photocatalyzed Atom Transfer Radical Addition Reactions Using an
- 2020 | Org. Process Res. Dev. | Optimization of a Decatungstate-Catalyzed C(Sp 3 )–H Alkylation Using a Continuous Oscillatory
- 2020 | Org. Process Res. Dev. | Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow
- 2020 | React. Chem. Eng. | An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride
- Magazine Articles
- Scientific Publications
- Areas of Interest
- Application Notes
- Events
- Jobs
- About us
- Contact
Optimization of a Decatungstate-Catalyzed C(Sp 3 )–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor
Tetrabutylammonium decatungstate (TBADT) has emerged as an efficient and versatile photocatalyst for hydrogen atom transfer (HAT) processes that enables the cleavage of both activated and unactivated aliphatic C–H bonds. Using a recently developed oscillatory millistructured continuous-flow photoreactor, investigations of a decatungstate-catalyzed C(sp3)–H alkylation protocol were carried out, and the results are presented here. The performance of the reactor was evaluated in correlation to several chemical and process parameters, including residence time, light intensity, catalyst loading, and substrate/reagent concentration. In comparison with previously reported batch and flow protocols, conditions were found that led to considerably higher productivity, achieving a throughput up to 36.7 mmol/h with a residence time of only 7.5 min.
Wen, Z.; Maheshwari, A.; Sambiagio, C.; Deng, Y.; Laudadio, G.; van Aken, K.; Sun, Y.; Gemoets, H. P. L.; Noël, T. Org. Process Res. Dev. 2020, 24 (10), 2356–2361.