- Home
- COSTA™ Technology
- Products
- HANU™ Flow Reactors
- Laboratory R&D
- HANU™ 2X 5
- Accessories
- Inlays
- HANU™ 2X 5 Inlay, cubic 2x2, stainless steel
- HANU™ 2X 5 Inlay, cubic 2x2, Hastelloy
- HANU™ 2X 5 Inlay, cubic 2x2, copper
- HANU™ 2X 5 Inlay, cubic 2x2, PTFE
- HANU™ 2X 5 Inlay, cubic 2x2, silicon carbide
- HANU™ 2X 5 Inlay, cubic 2x2, PEEK
- HANU™ 2X 5 Inlay, cubic 2x2, titanium
- HANU™ 2X 5 Inlay, cubic 1x1, Hastelloy
- HANU™ 2X 5 Inlay, cubic 1x1, Stainless steel
- In/outlet Ports
- Consumables
- Miscellaneous
- Inlays
- Accessories
- HANU™ 2X 5
- Process Development
- Pilot/Production
- Laboratory R&D
- MPDS® for Photochemistry
- Electrochemistry
- Previous Models
- HANU™ Flow Reactors
- Applications
- Application Notes
- Application Note 5: Electrochemical Oxidation of Diphenyl Sulfide enabled by the FAVO™ 5 Flow Reactor
- Application Note 4: Temperature Control in the HANU™ PX 9 Parallel Photoreactor
- Application Note 3: The use of the HANU™ reactor in combination with non-invasive inline Raman spectroscopy as a tool for a real
- Application Note 2: Photoinitiated thiol-ene coupling in flow
- Application Note 1: Synthesis of Cookson’s diketone via intramolecular [2+2] photocycloaddition
- Publications
- Scientific Publications
- 2022 | Chem. Eur. J. | Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor
- 2021 | Green Chem. | Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions
- 2021 | Green Chem. | Continuous Flow Processing of Bismuth-Photocatalyzed Atom Transfer Radical Addition Reactions Using an
- 2020 | Org. Process Res. Dev. | Optimization of a Decatungstate-Catalyzed C(Sp 3 )–H Alkylation Using a Continuous Oscillatory
- 2020 | Org. Process Res. Dev. | Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow
- 2020 | React. Chem. Eng. | An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride
- Magazine Articles
- Scientific Publications
- Areas of Interest
- Application Notes
- Events
- Jobs
- About us
- Contact
Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor
Continuous flow reactor technology has a proven track record in enabling photochemical transformations. However, transfer of a photochemical batch process to a flow protocol often remains elusive, especially when solid reagents or catalysts are employed. In this work, application of an oscillatory plug flow photoreactor enabled a heterogeneous MacMillan-type C(sp2)–C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)–C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity (0.87 g/h).
Debrouwer, W.; Kimpe, W.; Dangreau, R.; Huvaere, K.; Gemoets, H. P. L.; Mottaghi, M.; Kuhn, S.; van Aken, K. Org. Process Res. Dev. 2020, 24, 10, 2319–2325.