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Applications

Creaflow figure Selective and scalable oxygenation of heteroatoms using the elements of nature air water and light Beilstein Journal of Organic Chemistry

19 augustus 2023

Scientific publication: Selective and scalable oxygenation of heteroatoms using the elements of nature: air, water, and light

The study presents a selective and scalable oxygenation of heteroatoms using only air, water, and light. The approach is catalyst free, delivers high conversions with excellent selectivity, and works in batch as well as in flow. The…

Creaflow-Photoredox Csp3 Csp2 Reductive Cross Coup-ChemCatChemlings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow-ChemCatChem

12 oktober 2023

Scientific publication: Photoredox C(sp3)-C(sp2) Reductive Cross-Couplings of Cereblon Ligands for PROTAC Linker Exploration in Batch and Flow

The study reports a visible light driven reductive cross-coupling that forges C(sp3)-C(sp2) bonds from cereblon based substrates and aryl partners. The authors outline reaction conditions that are broadly applicable, enabling late stage…

Creaflow figure An electrochemical oscillatory flow reactor with pillar array electrodes improving mass transfer in electrosynthesis Science Direct 2x

20 december 2022

Scientific publication: An electrochemical oscillatory flow reactor with pillar array electrodes improving mass transfer in electrosynthesis

The study introduces an electrochemical oscillatory flow reactor that applies a controlled oscillatory flow regime over conductive pillar-array electrodes. These pillars function as both electroactive interface and turbulence promoters,…

Photochemical Deracemization of a Medicinally Relevant Benzopyran using an Oscillatory Flow Reactor

08 juli 2021

Scientific publication: Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor

Photo-transformation: Unlike classical enantiomeric resolution methods, crystallization-induced diastereomer transformations (CIDTs) allow full conversion to the desired enantiomer. 

Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor

08 juli 2021

Scientific publication: Continuous flow heterogeneous catalytic reductive aminations under aqueous micellar conditions enabled by an oscillatory plug flow reactor

Despite the fact that continuous flow processing exhibits well-established technical advances, aqueous micellar chemistry, a field that has proven extremely useful in…

Ontinuous flow processing of bismuth photocatalyzed atom transfer radical addition reactions using an oscillatory flow reactor v1 0

26 november 2020

Scientific publication: Continuous Flow Processing of Bismuth-Photocatalyzed Atom Transfer Radical Addition Reactions Using an Oscillatory Flow Reactor

Metal oxides represent an abundant and non-toxic class of photocatalysts for organic transformations. However, their use in larger scale processes is complicated by…

Rsz optimization of a decatungstate catalyzed csp3 h alkylation using a continuous oscillatory millistructured photoreactorv1 v1

09 juli 2020

Scientific publication: Optimization of a Decatungstate-Catalyzed C(Sp 3 )–H Alkylation Using a Continuous Oscillatory Millistructured Photoreactor

Tetrabutylammonium decatungstate (TBADT) has emerged as an efficient and versatile photocatalyst for hydrogen atom transfer (HAT) processes that enables the cleavage of both activated and unactivated aliphatic C–H bonds. 

Rsz toc graphic revised 1v1

04 juni 2020

Scientific publication: Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow Photoreactor

Continuous flow reactor technology has a proven track record in enabling photochemical transformations. However, transfer of a photochemical batch process to a flow protocol often remains elusive, especially when solid reagents or…

Rsz an oscillatory plug flow photoreactor facilitates semi heterogeneous dual nickel carbon nitride photocatalytic c n couplingsv1 3

14 februari 2020

Scientific publication: An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride Photocatalytic C–N Couplings

Carbon nitride materials have emerged as an efficient and sustainable class of heterogeneous photocatalysts, particularly when paired with nickel in dual catalytic cross-coupling reactions.

Appl note 5 toc v5 0

24 juni 2025

Application Note 5: Electrochemical Oxidation of Diphenyl Sulfide in the FAVO™ 5 Flow Reactor

The electrochemical sulfoxidation of Diphenyl sulfide is performed in the FAVO™ 5 flow reactor.

Appl note 4 toc v1 enlarged

24 juni 2025

Application Note 4: Temperature Control in the HANU™ PX 9 Parallel Photoreactor

Visible-light photoredox catalysis has been proven to be a powerful tool in modern organic synthesis. In order to screen photochemical reaction conditions and…

Creaflow application notes 3

24 juni 2025

Application Note 3: The use of the HANU™ reactor in combination with non-invasive inline Raman spectroscopy as a tool for a real-time kinetic study of a Diels-Alder reaction

The Diels-Alder reaction between α-terpinene and maleic anhydride was performed in the HANU™ reactor in order to determine the reaction kinetics through the process window via Raman spectroscopy.

Creaflow application notes 2 0

24 juni 2025

Application Note 2: Photoinitiated thiol-ene coupling in flow

The photoinitiated thiol-ene reaction between benzyl mercaptan and 1-decene yields 46 kg sulfide per day when performed in the HANU-reactor.

Creaflow application notes 1 0

24 juni 2025

Application Note 1: Synthesis of Cookson’s diketone via intramolecular [2+2] photocycloaddition

The intramolecular [2+2]-photocycloaddition leading to Cookson’s diketone 2 was performed in the HANU-reactor with a productivity of 2.3 kg/d.

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