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- 2022 | Chem. Eur. J. | Photochemical Deracemization of a Medicinally-Relevant Benzopyran using an Oscillatory Flow Reactor
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- 2020 | Org. Process Res. Dev. | Optimization of a Decatungstate-Catalyzed C(Sp 3 )–H Alkylation Using a Continuous Oscillatory
- 2020 | Org. Process Res. Dev. | Ir/Ni Photoredox Dual Catalysis with Heterogeneous Base Enabled by an Oscillatory Plug Flow
- 2020 | React. Chem. Eng. | An Oscillatory Plug Flow Photoreactor Facilitates Semi-Heterogeneous Dual Nickel/Carbon Nitride
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HANU™ reactor enables scalable protocol for slurry-based MacMillan metallaphotoredox Csp2-Csp3 coupling
13/04/2020 - 12:15
In their latest Organic Process Research & Development article, Ecosynth reports the application of the HANU™ reactor to enable a heterogeneous MacMillan-type C(sp2)–C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)–C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity.
