In the latest issue of Chemistry Today, Dr. Hannes Gemoets (Head of R&D Creaflow) comments in the Panel discussion on Flow Chemistry together with some of the most important Key Players in the field. Some of the hot topics discussed: Future perspectives on Drug approvals; Benefits & challenges to implementing Machine Learning; Potential for localized manufacturing; zero-waste target; The importance of courses in education.
In their latest Organic Process Research & Development article, Ecosynth reports the application of the HANU™ reactor to enable a heterogeneous MacMillan-type C(sp2)–C(sp3) cross-electrophile coupling. Combination of an oscillatory flow regime with static mixing elements imparts exquisite control over the mixing intensity and residence time distribution, pinpointing a mindset shift concerning slurry handling in continuous flow reactors. The C(sp2)–C(sp3) cross-electrophile coupling was successfully transferred from batch to flow, resulting in an intensified slurry process with significantly reduced reaction time and increased productivity.
In a recent article "An oscillatory plug flow photoreactor facilitates semi-heterogeneous dual nickel/carbon nitride photocatalytic C–N couplings" by the Kappe group, it was demonstrated that the HANUTM reactors can efficiently be used to perform scalable flow experiments with heterogeneous catalysts. Open access article